Abstract
Time-kill kinetics performed with tigecycline, in fresh MHB, demonstrated a consistent 1 to 2 log 10 CFU/ml reduction in bacterial counts against the majority of clinically relevant pathogens tested. Although classified as a bacteriostatic agent, tigecycline shows bactericidal activity against select isolates associated with serious infection. In general, vancomycin and imipenem demonstrated bactericidal activity.
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