Abstract
Hemocyanin (HCY) is a multifunctional glycoprotein, which plays multiple roles in immune defense in invertebrates. HCY from some mollusks can induce potent immune response, while little is currently known about how hemocyanin from arthropods affects tumors. In the present study, in vitro cytotoxic effect of HCY from two crab species Atergatis roseus and Eriphia verrucosa was investigated on two cell lines included hepatocellular carcinoma (HepG-2) and breast cancer (MCF-7). The results showed that HCY exhibited degrees of inhibitory activity against the two cell lines. HCY of A.roseus showed the highest cytotoxicity against HepG-2 cell line(IC50 :7.7 ± 3.1 mg/ml) while the HCY of E.verucossa showed inhibitory effect (IC50 : 9.5 ± 2.6 mg/ml) after 72 h. HCY of A.roseus and E.verucossa showed their maximum cytotoxity IC50 towards MCF-7 at 2.71± 1.3 mg/ml and 4.72± 1.5 mg/ml, respectively. In Conclusion, We concluded that HCY obtained from A. roseus has strong anti-tumor activity against HepG-2 and MCF-7 than HCY obtained from E. verrucosa
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
