Abstract
AIDS/HIV is a serious life-threatening and public health problem that urges for new antiviral drugs to control. A bis-indole alkaloid voacamine has been isolated from Voacanga africana Stapf. In this study, voacamine 1H and 13C chemical shift assignments were redetermined using 1D and 2D NMR; 1H NMR and 13C NMR chemical shifts were accurately assigned. Absolute configuration was confirmed by single-crystal X-ray diffraction analysis with Cu Kα radiation, and in vitro antiviral activity against HIV via effecting the binding affinity with gp120 based on SPRi experiment was testified. This study supports the potential value of voacamine as a natural agent against AIDS/HIV.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
