Abstract
BackgroundPolyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases and anti-oxidant properties.MethodsAnti-cholinesterase, anti-oxidant, and total phenolic and flavonoid contents were established using standard procedures.ResultsThe three polyherbal extracts exhibited significant concentration dependent acetylcholinesterase (AChE) inhibitory activity (P = 0.001). The highest AChE inhibition was observed with the Neocare Herbal Tea (NHT) with 99.7% (IC50 = 324 μg/mL); whereas the Herbalin Complex Tea (HCT) and Phytoblis Herbal Tea (PHT) exhibited 73.8% (IC50 = 0.2 μg/mL) and 60.6% (IC50 = 0.7 μg/mL) inhibition, respectively, relative to eserine at 100% inhibition (IC50 = 0.9 μg/mL) at 200 μg/mL. The order of percentage increase in inhibition of AChE was NHT > HCT > PHT; while the order of decrease in potency was HCT > PHT > NHT.Radical scavenging activities of HCT, NHT and PHT were 82.13% (IC50 = 0.08 μg/mL), 77.43% (IC50 = 0.01 μg/mL) and 76.28% (IC50 = 0.3 μg/mL), respectively, at 1 mg/mL concentrations. The reducing power revealed a dose-dependent effect, with NHT > PHT > HCT. The order of total phenolics content in the extracts were PHT > HCT > NHT, and for total flavonoids content: PHT > NHT > HCT.ConclusionThe three polyherbal standardised products possess significant acetylcholinesterase inhibitory activity and secondary metabolites that could collectively contribute to their memory-enhancing effects.
Highlights
Herbal medicines have witnessed a substantive growth in popularity underscored by their efficacy in alleviating a plethora of ailments
The three polyherbal standardised products possess significant acetylcholinesterase inhibitory activity and secondary metabolites that could collectively contribute to their memory-enhancing effects
The purpose behind the polyherbal standardisation is to assure to the consumer that the product retains the same chemical make-up and that this is consistent from batch to batch
Summary
Herbal medicines have witnessed a substantive growth in popularity underscored by their efficacy in alleviating a plethora of ailments. This increased usage likely reflects their availability, acceptability, and limited side effects [1]. Basic healthcare needs, such as drugs, are in short supply in many developing countries and a large proportion of the population patronise traditional and alternative medicine practitioners. Synthetic molecules have yet to completely attenuate medical conditions including dementias, such as Alzheimer disease (AD), and Parkinson disease (PD), the need for the continuous screening of indigenous medicines to discover suitable drugs to alleviate disease symptoms. Polyherbal standardised extracts used in ethnomedicine of Eastern Nigeria for memory improvements were evaluated for anti-cholinesterases and anti-oxidant properties
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