Abstract
Acetlycholinesterase (AChE) hydrolyses the neurotransmitter acetylcholine resulting in the termination of nerve impulse at the synapse. Anti-acetylcholinesterase activities stop the passage of the nerve impulse at the synapse resulting in continuous stimulation which can lead to death. The manufacturers of many pesticides target the AChE because it interferes with the passage of the nerve impulse. In vitro study revealed that DCM leaf extract of Carphalea glaucescens has anti-acetylcholinesterase activity against crude acetlycholinesterase (AChE) enzyme extracted from Chilo partellus and an IC50 of 12.02 mg/ml was calculated. After qualitative phytochemical screening was carried out the phytochemicals which were present were tannins, phenols, flavonoids, steroids, terpenoids and alkaloids.
Highlights
Acetylcholinesterase is the target for insecticides belonging to organophosphorus and carbamate group
Different conventional insecticides have been used to control stem borer resulting in high productivity but there are shortcomings in their application, including the high residue levels of pesticides in agricultural produce, pest resistance as well as environmental pollution [7]
The present study aimed to investigate the mode of action of C. glaucescens in the inhibition of acetylcholinesterase
Summary
Acetylcholinesterase is the target for insecticides belonging to organophosphorus and carbamate group. Different conventional insecticides have been used to control stem borer resulting in high productivity but there are shortcomings in their application, including the high residue levels of pesticides in agricultural produce, pest resistance as well as environmental pollution [7]. The management of C. partellus has been typically carried out by synthetic insecticides, which are non-biodegradable and not environmentally safe [8,9]. In this perspective, plants are considered the alternative sources of insect-control because they contain a range of bioactive compounds and many of which are selective. The present study aimed to investigate the mode of action of C. glaucescens in the inhibition of acetylcholinesterase
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