Abstract
Objective: The development of anthelmintic activity and the high cost of synthetic anthelmintic drugs it leads to the evaluation of medicinal plants as an alternative source of anthelmintics. In the current study, in vitro experiments were conducted to determine the possible anthelmintic effects of crude methanolic, aqueous, and hydroalcoholic extracts of the stem bark of Maytenus emarginata on eggs and adult Pheretima posthuma and Ascaridia galli. 
 Methods: Three concentrations (10, 25, and 50 mg/ml) of methanolic, aqueous, and hydroalcoholic extracts of plant M. emarginata were studied in activity which involved the determination of the time of paralysis (called as vermifuge) and time of death (called as vermicidal) of the worms. Piperazine citrate in same concentration as those of extract was included as standard reference and normal saline water with 1% carboxymethyl cellulose as control.
 Results: The methanolic, aqueous, and hydroalcoholic extracts exhibited significant anthelmintic activity at a concentration of 50 mg/ml. Peak activity was exhibited by the methanolic extract at a concentration of 50 mg/ml.
 Conclusion: The overall findings of the present study have shown that M. emarginata contain possible anthelmintic compounds and further evaluation of these plants should be carried out. The traditional use of anthelmintic activity of this plant is genuine.
Highlights
Helminth parasite infection is one of the most major global problems with serious social and causes economic impact in the third world countries including India
The overall findings of the present study have shown that M. emarginata contain possible anthelmintic compounds and further evaluation of these plants should be carried out
The methanolic extract of the stem bark of plant M. emarginata time of paralysis is 9.36 min and time of death is 23.43 min, and hydroalcoholic extract revealed that the time of paralysis is 18.88 min and time
Summary
Helminth parasite infection is one of the most major global problems with serious social and causes economic impact in the third world countries including India. Global estimates have found out that many of peoples all over the world are infected by helminth parasites [1]. Parasitic infection including helminthiasis is a critical serious problem in the tropical regions including the Asian and African countries which affects more than 2.5 billion of people worldwide [2]. Maytenus emarginata is an evergreen tree that tolerates various types of stresses of the desert It is commonly known as Thorny staff tree in English and Kankero in Hindi. We have attempted to investigate methanolic, hydroalcoholic, and aqueous extracts of the stem bark of medicinal plant M. emarginata for their claimed anthelmintic activity
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