Abstract
We analyzed susceptibility to anidulafungin of yeasts clinical strains of Candida (14 species), Cryptococcus (1 species), Geotrichum (1 species), Rhodotorula (1 species) and Saccharomyces (1 species). We revealed high anidulafungin activity against Candida spp., both common species and rare pathogens of candidiasis. It was found that over 99 % of Candida strains do not have an acquired resistance mechanisms to anidulafungin (microbiological criteria). The anidulafungin is not active against strains of Cryptococcus neoformans and Rhodotorula mucilaginosa.
Highlights
We analyzed susceptibility to anidulafungin of yeasts clinical strains of Candida (14 species), Cryptococcus (1 species), Geotrichum (1 species), Rhodotorula (1 species) and Saccharomyces (1 species)
We revealed high anidulafungin activity against Candida spp., both common species and rare pathogens of candidiasis
Установленные значения минимальных подавляющих концентраций (МПК) анидулафунгина для G. candidum (0,03–0,06 мкг/мл) и S. cerevisiae (0,12 мкг/мл) не предполагают наличие устойчивости in vitro к препарату у протестированных штаммов данных видов грибов и, напротив, могут свидетельствовать об их чувствительности in vitro
Summary
We analyzed susceptibility to anidulafungin of yeasts clinical strains of Candida (14 species), Cryptococcus (1 species), Geotrichum (1 species), Rhodotorula (1 species) and Saccharomyces (1 species). Чувствительность к анидулафунгину была протестирована у 168 клинических штаммов дрожжевых грибов следующих родов: Candida (39 штаммов C. albicans, 4 – C. dubliniensis, 2 – C. famata, 32 – C. glabrata, 3 – C. guilliermondii, 4 – C. kefyr, 24 – C. krusei, 3 – C. lipolytica, 2 – C. lusitaniae, 1 – C. norvegensis, 10 – C. parapsilosis, 2 – C. rugosa, 17 – C. tropicalis, 2 – C. zeylanoides); Cryptococcus (6 – Cr. neoformans); Geotrichum (3 – G. candidum); Rhodotorula (10 – R. mucilaginosa); Saccharomyces (4 – S. cerevisiae).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
