In vitro and in vivo studies on the wound healing activity of leaf extracts of Homalium zeylanicum benth

Abstract

In this study, the Indian medicinal herb Homalium zeylanicum benth was tested for its ability to cure wounds. A variety of solvents have been used to extract the leaves of the plant. Leaf extract was used for wound healing research both in the laboratory and in animals. HaCaT cells were used to investigate the cytotoxicity of plant extracts, and the IC50 values for the various leaf ethyl acetate extracts were determined. All doses of the test samples indicated reduced cytotoxicity on the tested cell line. Scratch assays were used to measure the migration rates of HaCaT cells. During an in vivo study, animals treated with ethyl acetate leaf extract had higher percentages of wound contraction power and tensile strength.. According to this study, the plant's leaf extract may have wound-healing properties, which is in line with its traditional medicinal uses.