In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi

J S De Araújo,D G J Batista,A A Farahat,M F V Da Silva,M N C Soeiro,D W Boykin,M Banerjee,P B Da Silva,C A F Aiub,M B Meuser,A Kumar,C F Araújo-Lima,C E Stephens,C F Da Silva

doi:10.1128/aac.01403-13

In Vitro and In Vivo Studies of the Biological Activity of Novel Arylimidamides against Trypanosoma cruzi

J S De Araújo, D G J Batista + Show 12 more

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https://doi.org/10.1128/aac.01403-13

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Journal: Antimicrobial agents and chemotherapy	Publication Date: Mar 3, 2014
Citations: 13

Affiliation: Fundação Oswaldo Cruz, Mansoura University, Georgia State University, Rio de Janeiro State University, Augusta University

#Arylimidamides #Number Of Units

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Abstract

Fifteen novel arylimidamides (AIAs) (6 bis-amidino and 9 mono-amidino analogues) were assayed against Trypanosoma cruzi in vitro and in vivo. All the bis-AIAs were more effective than the mono-AIAs, and two analogues, DB1967 and DB1989, were further evaluated in vivo. Although both of them reduced parasitemia, protection against mortality was not achieved. Our results show that the number of amidino-terminal units affects the efficacy of arylimidamides against T. cruzi.

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