In vitro and in vivo studies of a new antibiotic, fumagillin, with Endamoeba histolytica.

Abstract

Summary1. A new antibiotic, fumagillin (“Antibiotic H-3”), was found to be effective in vitro against E. histolytica at concentrations of 1:10,000,000 to 1: 15,000,000. 2. Preliminary in vivo studies on monkeys naturally infected with E. histolytica indicated that fumagillin possesses considerable amebacidal activity. Further investigations are necessary to evaluate this drug more completely.