Abstract
To enhance biocompatibility, osteogenesis, and osseointegration, we coated titanium implants, by krypton fluoride (KrF) pulsed laser deposition, with a thin film of fluoridated hydroxyapatite (FHA). Coating was confirmed by scanning electron microscopy (SEM) and scanning probe microscopy (SPM), while physicochemical properties were evaluated by attenuated reflectance Fourier transform infrared spectroscopy (ATR-FTIR). Calcium deposition, osteocalcin production, and expression of osteoblast genes were significantly higher in rat bone marrow mesenchymal stem cells seeded on FHA-coated titanium than in cells seeded on uncoated titanium. Implantation into rat femurs also showed that the FHA-coated material had superior osteoinductive and osseointegration activity in comparison with that of traditional implants, as assessed by microcomputed tomography and histology. Thus, titanium coated with FHA holds promise as a dental implant material.
Highlights
Teeth are crucial to mastication, phonation, and aesthetics and are an important component of the mouth–jaw system [1]
The American Academy of Implant Dentistry defines osseointegration as “contact established without interposition of nonbone tissue between normal remodeled bone and an implant, entailing sustained transfer and distribution of load from the implant to and within bone tissue.”
Of these, pulsed laser deposition has emerged in the last 15–20 years as one of the most popular, efficient, and straightforward techniques to deposit a wide spectrum of materials, especially on targets with complex shapes, including implants
Summary
Teeth are crucial to mastication, phonation, and aesthetics and are an important component of the mouth–jaw system [1]. Conventional, unmodified Ti implants may not withstand heavy occlusion in the early period of implantation and require at least three months of stress-free healing [7] Such long recovery times may not be acceptable to patients who wish to quickly regain aesthetic appearance and function and may increase the risk of infection, other periodontal issues, and even implant failure. Novel surface-coating treatments, including sol-gel, chemical vapor phase deposition, and pulsed laser deposition (PLD), may accelerate osseointegration [8,9,10]. Of these, pulsed laser deposition has emerged in the last 15–20 years as one of the most popular, efficient, and straightforward techniques to deposit a wide spectrum of materials, especially on targets with complex shapes, including implants. The morphology and physicochemical properties of the film were assessed, along with osseointegration and osteogenic activity in vivo and in vitro
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