Abstract

In vitro and in vivo investigations on anti-influenza effect of adamantyl (alkyl, cycloalkyl) derivatives of aminopropanol-2

Highlights

  • For today in the world and in Ukraine in particular, is unstable epidemic situation for many infectious diseases, including viral

  • The anti-influenza activity of new synthesized adamantyl derivatives of aminopropanol-2 was studied against the influenza virus strain A/FM/1/47(H1N1)

  • maximum tolerated dose (MTD) of the tested compounds was determined by their cytotoxic effect on a monolayer of the Madin-Darby Canine Kidney (MDCK) cells culture

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Summary

Introduction

For today in the world and in Ukraine in particular, is unstable epidemic situation for many infectious diseases, including viral. According to the WHO estimates by 2030, infection diseases will be one of the major causes of mortality among people Influenza is a lea­der among the respiratory tract infections by the. Airborne droplets way of distribution of flu infection leads to the rapid spread of the pathogen, and high antigenic variability of the influenza virus results in the appearance of new strains causing epidemics and pandemics. The flu and acute respiratory viral infections annually affect about 15 million people in Ukraine [1]. Despite the recent achievements in diagnostics and therapy, the problem of treatment of influenza remains a relevant problem, as well as the establishment of effective chemotherapeutic agents for prevention and therapy of this infection. The best of them is aminoadamantane (amantadine, rimantadine) [3, 7], which entered the pharmaceutical market and is successfully used as an anti-influenza drug

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