In vitro and in vivo examination of the osteogenic ability of 3d scaffold chitosan-hydroxyapatite : a systematic review

Abstract

Background: Alveolar bone resorption in dentistry cases can be caused by several factors. Some of which are periodontal disease, post-tooth extraction trauma, post enucleation cyst, and post-tumor surgery. The idea of bone tissue engineering, especially biomaterials will be focused on precise scaffold design in terms of physicochemical in cell adhesion, proliferation, differentiation, and specific organ tissue formation. Chitosan can be combined with Hydroxyapatite in form of scaffold 3D design for bone remodeling procedure. Purpose: discover Osteogenic ability with scaffold 3D chitosan-Hydroxyapatite in vitro and in vivo. Method: utilizing literature review by collecting, compiling similarities, and concluding references related to Osteogenic ability with scaffold 3D chitosan-Hydroxyapatite in vitro and in vivo on bone remodelling process. Results: based on journal research with keywords of 3D Scaffold, Chitosan, Hydroxyapatite, Bone Engineering, in vitro and in vivo, a total of 15 journal articles were used as references. Conclusion: Scaffold integrates bone tissue and provide effective room for new bone formation. Scaffold 3D ( combination of chitosan and collagen) plays significant part in bone regeneration and becomes natural polymer containing ion complex as to maximalize characteristics of osteoconductivity contained. Scaffold chitosan/hydroaxipatite possesses osteogenic ability integral to repair bone fracture.