Abstract
The present study reports the in-vitro and in-vivo anti-inflammatory potency of Mesua ferrea, Saraca asoca, Viscum album and Anthocephalus cadamba, potent medicinal plants of Western Ghats of Karnataka India. Lipopolysaccharide (LPS)-activated murine macrophage RAW 264.7 cell line was used in in-vitro assay. Pretreatment with methanolic extracts at non toxic concentrations abridged the LPS-induced protein levels. Among the four plants tested, methanolic extract of Viscum album (70.20 ± 1.094) and Mesua ferrea (68.29 ± 2.862) showed potent anti-inflammatory activity at 100 µg concentration with an IC50 value of 57.23 ± 1.922 and 63.36 ± 3.791 µg/ml. In vivo anti-inflammatory activity was evaluated using carrageenan-induced paw edema in Wistar albino rats, Viscum album (0.6167 ± 0.01667) and Mesua ferrea (0.6833 ± 0.01667) showed potent anti-inflammatory activity (at 100 mg/kg.bw). The obtained results indicate the potency of active constituents of Mesua ferrea and Viscum album in the development of effective anti-inflammatory drugs.
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