Abstract
We present P(TMC-co-DLLA) copolymer with the molar ratio of TMC: DLLA = 15: 85 was used to systematic study of in vivo and in vitro degradation behaviors. Dense homogeneous copolymer specimens were prepared by compression molding method. The in vitro and in vivo degradation were, respectively, performed at simulative body condition and implanted into rat’s subcutaneous condition. Investigations were followed via physicochemical and histological analysis such as SEM, GPC, DSC, FTIR and H&E stain. The results demonstrate that copolymeric material can degrade in phosphate buffer solution (PBS) and in rat’s body, and the in vivo degradation rate is faster. Obvious decline of molecule weight and mass loss has been observed, which led to the attenuation of mechanical strength. Furthermore, apart from the hydrolysis, macrophagocytes took part in the phagocytosis in vivo, indicating that degradation rate could be regulated by the combinational mechanism. It is concluded that P(TMC-co-DLLA) copolymer is a promising candidate for tissue repair.
Highlights
Synthetic biodegradable polymers have been studied proverbially and widely used for biomedical applications because of their excellent biodegradability, mechanical properties, minor cytotoxicity and immunogenicity [1,2,3,4,5,6]
Other than the ‘bulk degradation mode’ of PDLLA, PTMC has been shown to degrade by surface erosion approach [18, 19], avoiding the sharp attenuation of mechanical strength during fragmentation of the matrix
PDLLA cleaves by hydrolysis into acidulous lactic acid [20, 21], which has an adverse effect on surrounding tissue
Summary
Synthetic biodegradable polymers have been studied proverbially and widely used for biomedical applications because of their excellent biodegradability, mechanical properties, minor cytotoxicity and immunogenicity [1,2,3,4,5,6]. Copolymers composed of different blocks are likely to improve the combinational behaviors including biodegradation rate, mechanical properties and cell affinity behavior, etc [9,10,11,12]. PDLLA and PTMC are well known polymers that can be applied in intravitreal delivery systems or bone defect [13,14,15], mostly in the form of scaffolds and microspheres [16, 17]. It has been demonstrated that enzymes and reactive oxygen species secreted by phagocytic cells play an important role in the in vivo degradation of PTMC [22, 23], and it degrades without the formation of acidic compounds, which is an advantage as regenerative material.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
