IN VITRO AND IN VIVO ANTIDIABETIC EFFECTS OF SALACIA OBLONGA WALL LEAF AND ROOT EXTRACTS

Abstract

The present study was framed out to evaluate the antidiabetic effects of S. oblonga Wall leaf and root ethyl acetate and toluene extracts in vitro and in vivo. The root ethyl acetate extract found significant inhibition of alpha amylase and alpha glucosidase enzyme functions in vitro. The in vivo studies are carried out according to the guide line of CPCSEA and IAEC. The acute toxicity test of the extracts resulted in the no effect on the animals. The ethyl acetate extract of root showed the increase in body weight of animals at the end of the experiment. The blood glucose levels of diabetic rats are significantly reduced after the treatment of root ethyl acetate extract. The leaf toluene and ethyl acetate extract exhibited average antidiabetic activity. We conclude that root extract exhibited good antidiabetic activity comparing to leaf extract.