Abstract
In Korean folk medicine, Artemisia iwayomogi has largely been employed for the improvement of diabetic complications and hepatic function as well as in the treatment of female diseases and skin whitening. Accordingly, the present study sought to assess cosmeceutical activity of Artemisia iwayomogi. Through activity-guided fractionation, scopolin (AI-1), 2,4-dihydroxy-6-methoxy-acetophenone 4-O-β-D-glucoside (AI-2), scopoletin (AI-3), kaempferol-3-O-methyl ether (AI-4) and luteolin (AI-5) were isolated from ethyl acetate and water fractions of Artemisia iwayomogi. Of them, AI-4 and AI-5 exhibited strong antioxidative and whitening effects. In addition, AI-1, AI-3, AI-4, and AI-5 demonstrated considerable anti-wrinkle performances. According to results of quantitative analysis of compounds isolated from Artemisia iwayomogi, scopolin (AI-1) is a major component of Artemisia iwayomogi. Moreover, O/W type cream made by water fraction which included scopolin showed unwrinkling effect for 8 weeks when it was applied to face in an in vivo study. Specific contributions of Artemisia iwayomogi were as follows: AI-1, 1.21 mg/g; AI-2, 0.26 mg/g; AI-3, 0.38 mg/g; AI-4, 0.01 mg/g; and AI-5, 0.04 mg/g.
Highlights
Artemisia iwayomogi, called Haninjin or Deowijiki, is a native plant that naturally grows across Korea beginning in spring (Jung et al, 2008)
These compounds were confirmed based on their spectroscopic values (1H-NMR, Carbon nuclear magnetic resonance (13C-NMR), Fast atom bombardment mass spectrometry (FAB-MS), UV) that were consistent with literature values: scopolin (Bayoumi et al, 2008), 2,4-dihydroxy-6-methoxy-acetophenone-4-O-ßD-glucopyranoside (Singh et al, 1997), scopoletin (Bayoumi et al, 2010), kaempferol-3-O-methyl ether (Urbatsch et al, 1975), and luteolin (Kim et al, 2000)
Antioxidant activity Antioxidant activities of isolated compounds were measured using DPPH and superoxide scavenging activity assays with xanthine oxidase and an antioxidative activity test using ABTS
Summary
Called Haninjin or Deowijiki, is a native plant that naturally grows across Korea beginning in spring (Jung et al, 2008). Traditional Korean medicine has widely employed Artemisia iwayomogi for its anti-tumor, immune-modulating, anti-mutagenic, anti-oxidant, anti-bacterial, anti-fungal, anti-pyretic, diuretic, liver protective, choleretic and diabetic complications relieving effects among others (Seo & Yun, 2008; Lee et al, 2013; Lee et al, 2017). Within the framework of traditional medicine, Artemisia iwayomogi has been used as herbal medicine to treat jaundice caused by acute hepatitis elicited by humidity. It is used to treat urination problems, itchy skin, chronic hepatitis, hepatic sclerosis and fever (Jang et al, 2012).
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