Abstract
In folk remedies, the whole plant of Ph yllanthus rheedii is used to treat diabetes. This study aimed to investigate the in vitro and in silico antidiabetic effects of isolated Phthalic Acid 1 - (8 - Methyl - Non - 2 - Enyl) Ester 2 - Tetradecyl Ester from the chloroform extract of whole plant of Phyllanthu s rheedii and AMP kinase activation property of the isolated compound. The Phthalic acid binds very efficiently within the active pocket of AMPK with the formation of 2 hydrogen bonds which is good when compared to orientation of standard drug Metformin. I n in vitro antidiabetic evaluation of STZ treated chick embryo , the administration of isolated compound at a doses of 0.5 mg/egg and 1 mg/egg produced a significant reduction in the blood glucose levels in a dose dependan t manner (p < 0.01). The blood glucose level of diabetic control was 244.2 ± 12.64 mg%, whereas it was 207.4 ± 2.43 mg% (P < 0.001) for isolated compound at dose of 0.5 mg/egg and 174.8 ± 2.410 mg% (P < 0.001) for dose of 1 mg/egg of the isolated compound. The significant glucose levels were reduced (p < 0.01) after administration of the compound.
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