Abstract
Analysis of anaphase and metaphase chromosome preparations from a series of human embryo lung (HEL) fibroblast-like lines and a similar series of human embryo kidney (HEK) epithelioid lines revealed a notable similarity of chromosome aberration profiles between the two cell types despite the marked reduction in total population doublings (PDs) achieved by the epithelioid lines. Among the similarities noted were: (1) Significant increases in polyploid cells but not breakage type aberrations during the earliest passages following explantation; (2) typically low levels of all aberrations among mid-passage cultures; and (3) subsequent increases in polyploidy and breakage type aberrations as the cultures approached senescence. The data from these studies are discussed in relation to current theories of cellular senescence.
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