In-Vitro Adsorption of Cholate Anion at pH 7.5 by Aluminum Hydroxide

Abstract

The in-vitro adsorptive capacities of aluminum hydroxide gel, dried aluminum hydroxide gel, and boehmite for cholate anion were determined at pH 7.5, 37°C and compared to cholestyramine. The adsorptive capacity of aluminum hydroxide gel was similar to cholestyramine. However, spray drying reduced the adsorptive capacity by approximately 50%. Boehmite, a crystalline aluminum oxyhydroxide, had an adsorptive capacity similar to dried aluminum hydroxide gel. The results support the hypothesis that adsorption of bile salts contributes to the constipation which is sometimes associated with aluminum hydroxide therapy.