Abstract
Background and Aims: Adenosine deaminase (EC 3.5.4.4, ADA) is distributed in all human tissues. It catalyses the deamination of adenosine (deoxyadenosine) to inosine (deoxyinosine) via removal of an amino group. The determination of ADAinhibition is of extreme significance in the field of fundamental research and clinical diagnosis. In our study, the effects of various plant extracts and chemicals on ADA activity were investigated. Methods: Adenosine deaminase activity was determined spectrophotometrically at 625 nm. Results: The inhibitory activities of the extracts and chemical compounds increased in a dose-dependent manner. Among the plant extracts used, lemon extract was observed to exhibit the highest ADA inhibition activity with an IC50 value of 0.05 ± 0.001 mg/mL, while quercetin had the highest ADA inhibition (IC50 value of 0.004±0.0005 mg/mL) among the chemical compounds. All plant extracts and chemical compounds showed ADA inhibition activities. Conclusion: The obtained results indicate that plant extracts and some chemical compounds examined in this study can be a potential source of novel ADA-inhibitors for therapeutics.
Highlights
Cancer is a complicated disease that varies from one patient to another in terms of manifestation, development and outcomes
We investigated adenosine deaminase activity of some selected plant extracts and chemical compounds
The ADA inhibitor activities of plant extracts and chemical compounds were found to increase in a dose dependent manner
Summary
Cancer is a complicated disease that varies from one patient to another in terms of manifestation, development and outcomes. The most important factors in the development of cancer include the use of tobacco and tobacco products, alcohol consumption, malnutrition, obesity, viruses, exposure to ionizing radiation, occupational diseases and environmental pollution (Soerjomataram et al, 2018). Different treatment modalities such as chemotherapy, radiotherapy, surgical methods, hormone therapy and biological methods have been the main methods of cancer treatment.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
