Abstract
A total of 33 Stenotrophomonas maltophilia clinical isolates were tested for their susceptibility to clinafloxacin in comparison with ciprofloxacin, levofloxacin, moxifloxacin, nalidixic acid, norfloxacin, sparfloxacin and trovafloxacin. The MIC 50 and MIC 90 were as follows: ciprofloxacin 4 and 64 μg/mL; clinafoxacin 0.5 and 4 μg/mL; levofloxacin 2 and 32 μg/mL; moxifloxacin 1 and 8 μg/mL; nalidixic acid 8 and 128 μg/mL; norfloxacin 64 and 256 μg/mL; sparfloxacin 1 and 16 μg/mL; and trovafloxacin 1 and 8 μg/mL. Clinafloxacin was the most active quinolone, with only a 15.1% of strains showing resistance. When the MICs were determined in the presence of 25 μg/ml of reserpine, the MIC 90 of trovafloxacin and moxifloxacin did not change, whereas decreased 2-fold for clinafloxacin, levofloxacin, sparfloxacin and nalidixic acid, and 4- and 8-fold for ciprofloxacin and norfloxacin respectively. No clinafloxacin-resistant strains were observed when the MIC was performed in the presence of reserpine. Therefore, clinafloxacin shows the better “in vitro”activity against these 33 strains of S.maltophilia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
