Abstract
Trichophyton tonsurans is the most common agent causing tinea gladiatorum in wrestlers, and limited data on susceptibility profiles of Trichophyton tonsurans are available. We aimed to assess the in vitro activity of the common antifungal drug against a large collection of Ttonsurans. The in vitro activities to eight common antifungal drugs (sertaconazole, itraconazole, clotrimazole, fluconazole, butenafine, tolnaftate, terbinafine and griseofulvin) against 128 clinical isolates of Ttonsurans strains, obtained from wrestlers with dermatophytosis, were performed according to CLSI M38-A2 broth microdilution document. The geometric mean minimum inhibitory concentration was the lowest for tolnaftate (0.022µg/mL), followed by itraconazole (0.026µg/mL), terbinafine (0.033µg/mL), butenafine (0.088µg/mL), griseofulvin (0.566µg/mL), sertaconazole (2.875µg/mL), clotrimazole (3.419µg/mL) and fluconazole (12.540µg/mL). Evaluation of antifungal susceptibility of dermatophytes showed that tolnaftate and itraconazole were the most effective drugs against T tonsurans and fluconazole had the least effect.
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