Abstract
Fragments of rat ventral prostate were incubated in vitro with [7- 3H]-testosterone and the effect of some compounds on testosterone metabolism in this system was studied. Progesterone, 17-hydroxyprogesterone and ethynylestradiol inhibited the formation of dihydrotesterone (DHT), 3α-androstanediol, 5α-androstanedione and androsterone. There was a concomitant apparent stimulation of 17β-hydroxysteroid dehydrogenase activity. Medroxyprogesterone acetate (MPA) had no effect on formation of DHT but inhibited formation of 3α-androstanediol. This inhibition of 3a-hydroxysteroid dehydrogenase activity was confirmed when [4- 14C]-DHT was incubated with the prostatic tissue in the presence of MPA. Prostaglandin E 2 or the presumed absence of prostaglandins had no effect on 5α-reduction of testosterone in this system.
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