Abstract
Atrazine is a common herbicide that has been implicated in multiple health issues. The enzyme that degrades atrazine is Glutathione S‐Transferase (GST). GST is a detoxifying enzyme present in high concentrations in the liver; the GST isoenzyme pi is specifically responsible for the breakdown of atrazine. Previous research showed decreased expression of GST when mice are exposed to atrazine. Studies have also shown that there is circadian regulation of GST. This study investigated the effect atrazine had on circadian rhythm of GST by utilizing CD‐1 mice exposed in utero to atrazine. The results showed that atrazine inhibited the circadian rhythm of not just GST, but also Period 1, a circadian regulating protein.
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