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Abstract

PROTEOMICSVolume 11, Issue 18 In this issue In this issue First published: 06 September 2011 https://doi.org/10.1002/pmic.201190097AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Abstract Tag-along bio-markers for pancreatic problems Problems, problems, problems… Among the most difficult organ cancers to diagnose, those of the pancreas rank near the top. Pancreatic cancer is stealthy, often progressing to incurable before it is recognized. Ideally, the disease should be detected at an early stage where it can be treated appropriately and optimally. Such a tool would also contribute to development of new and effective therapies. At present, the best assay for pancreatic cancer is CA 19-9. This is not a pancreas-specific test, giving positive signals for other cancers as well, lacking both specificity and sensitivity required for a valid test. Yue et al. explored the carrier space of CA 19-9 using proteomic tools for carbohydrate carriers and found better but still insufficient correlations with state of the art MS techniques. They confirmed previously identified ApoE and ApoB, but neither with sufficient signal strength. pp. 3665–3674 Q. Wilson's disease (ATP7B): why bother with it? A. have you looked at the price of copper lately? The old British copper penny would have to be the size of a watermelon to get its scrap value above its cash value today. If you have WD, you are carrying around copper deposits in your eyes and other tissues. Therapy involves using copper-transporting chelators to remove the copper from body tissues and excrete through the kidneys – not a trivial procedure. Approximately 1 in 40 000 of world's population carries the genetic defect (ATP7B). An animal model (Long-Evans Cinnamon (LEC) rats) exhibits most of the human liver symptoms of WD. Lee et al. used standard proteomic tools: IPG first dimension and SDS-PAGE for the second. Mass spectrometry was performed on a MALDI-TOF MS after in-gel digestion. Other, previously unrecognized enzymes were also turned up. Thanks for offering, but I do not think we can harvest our friends and coworkers. pp. 3698–3705 Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor EGFR is on the short list of anti-tumor targets for its collaboration in development of several types of solid tumors. Adding insult to injury, the tumors do not respond to EGFR inhibitors consistently and have multiple survival pathways. A new therapeutic approach uses histone deacetylase inhibitors (HDAC-Is) – they are very selective, altering transcription of 2–5% of actively expressed genes. Bianchi et al. explored the roles of two EGFR inhibitors (vorinostat and gefitinib), and their quantitative synergies by 2-D DIGE MALDI-TOF-MS and ESI-Ion trap MS. Selected interaction networks were validated by western blots. pp. 3725–3742 Volume11, Issue18No. 18 September 2011 RelatedInformation