Abstract
Photobiology has been part of the JID from its inception. In April 1939 (JID 2:4351,1939), Stephan Epstein described experiments performed in six individuals, including himself, and introduced and defined the concept of photoallergy. After intradermal injection of sulfanilamide, natural sunlight or artificial light sources were applied and all individuals had an acute reaction. After 10 d, without further irradiation, two of the volunteers had an ''urticarial reaction'' that lasted for 10 - 14 d. This delayed reaction was defined as ''photoallergic'', and the precise mechanisms by which UV light induces allergy are still under study 63 y after Epstein's article.
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