In-situ two-step electrodeposition of α-CD-rGO/Ni-MOF composite film for superior glucose sensing

Abstract

Accurate and rapid determination of blood glucose levels is essential for real-time monitoring and management of diabetes mellitus, and nanomaterials-based nonenzymatic glucose sensing plays an increasingly significant role in this regard. Here, a simple two-step electrodeposition technique that was efficient, environmentally friendly, easily manipulated, and exceedingly controllable was adopted for the synthesis of metal-organic framework (MOF)/carbon material composites on a titanium mesh (TM), namely α-cyclodextrin functionalized reduced graphene oxide/nickel-based MOF (α-CD-rGO/Ni-MOF/TM), in which Ni-MOF served as the electrocatalyst for glucose oxidation, and rGO greatly enhanced the electrochemical performance of Ni-MOF, benefiting from α-CD effectively preventing aggregation of rGO nanosheets while also improving the stability of the composites, so that these endow the obtained nanomaterials exhibited remarkable electrocatalytic ability for glucose. Consequently, the as-prepared glucose sensor revealed two linear dynamic ranges of 0.65 μM− 4.828 mM with a sensitivity of 1395 μA mM−1 cm−2 and 4.828 − 9.178 mM with a sensitivity of 760 μA mM−1 cm−2 together with a rapid response time of only 1.9 s and a low detection limit of 0.3 μM as well as distinguished reproducibility, selectivity, and stability, further demonstrating the synergistic effects of this composite. The newly manufactured glucose sensing platform was also successfully used to detect glucose in real serum. Considering the convenience and controllability of two-step electrodeposition, the α-CD-rGO/Ni-MOF/TM composite holds great promise for commercial potential, and also provides direction and technical reference for the synthesis of MOF/carbon material composites.