Abstract
HighlightsA one-pot method was developed for the preparation of fluorescent mesoporous silica nanoparticles–carbon dots (MSNs–CDs) nanohybrid.The MSNs–CDs nanohybrid showed stable and bright yellow emission, excellent biocompatibility, and specific targeting capability toward folate receptor-overexpressing cancer cells and can be applied as fluorescence imaging-guided drug carriers for effectively delivering anticancer drugs to tumor sites.
Highlights
Cancer has become one of the most severe public health problems globally [1]
After cell culture in a 5% C O2 incubator at 37 °C for 24 h, the culture medium was discarded, and the cells were treated with another 100 μL of Dulbecco’s modified Eagle’s medium (DMEM) containing mesoporous silica nanoparticles (MSNs)–Carbon dots (CDs)@ DOX at a concentration range of 0–100 μg mL−1 and equivalent concentration of free DOX for 24 h
folic acid (FA) was recently used as a carbon resource for the synthesis of CDs, which still retained the capability for targeting folate receptors (FRs)-overexpressing cancer cells [55, 56]
Summary
Cancer has become one of the most severe public health problems globally [1]. Currently, chemotherapy is still the major treatment of choice in most cases [2]. To depress the toxic side effects and simultaneously enhance the therapeutic efficacy, the utilization of targeted drug delivery systems (DDSs) has attracted broad attention [4,5,6,7]. In the past few years, various nanomaterials, including micelles [8, 9], liposomes [10, 11], viruses [12, 13], and capsules [14, 15], with good biodegradability and facile functionalization have been designed as DDSs to target cancer cells These nanomaterials tend to suffer from various biochemical attacks and bioerosion, such as enzymatic degradation, on account of their inherent instability in vivo [16,17,18]
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