In situ synthesis and characterization of colloidal AuNPs capped nano-chitosan containing poly(2,5-dimethoxyaniline) nanocomposites for biomedical applications

Abstract

Herein, we have successfully synthesized a novel nCS-PDMA/AuNPs nanocomposite based on nano-chitosan containing poly(2,5-dimethoxyaniline) capped gold nanoparticle in situ synthesis is reported. The AuNPs were synthesized using the green method without using any harmful chemicals, reducing and stabilizing agents to generate AuNPs, is not needed because these roles are played by nCS. The synthesized nCS-PDMA/AuNPs nanocomposite were characterized by UV-Vis, FT-IR, XRD, SEM, and TEM analysis. The polydispersed nCS-PDMA/AuNPs nanocomposite was observed approximately 25 nm. Furthermore, nCS-PDMA/AuNPs nanocomposite was showed significant antibacterial activity against S. aureus and E. coli. The nCS-PDMA/AuNPs nanocomposite showed strong antioxidant activity by inhibiting the DPPH radicals. In addition, the cytotoxicity of nCS-PDMA/AuNPs nanocomposite was tested in HeLa cells and found to be high toxicity than nCS-PDMA. This work suggests that green synthesized nCS-PDMA/AuNPs nanocomposite may be utilized as an effective antibacterial, antioxidant, and anticancer activity. Research highlights nCS-PDMA capped gold nanoparticles (nCS-PDMA/AuNPs) were prepared. Physical characterization of nCS-PDMA/AuNPs by UV-vis, FTIR, XRD, SEM, and TEM. nCS-PDMA/AuNPs displayed promising inhibitory activity against both bacteria. nCS-PDMA/AuNPs showed significant DPPH radical scavenging activities. nCS-PDMA/AuNPs showed an excellent anticancer activity against HeLa cells.