Abstract
Novel luminescent mesoporous silica nanoparticles (MSNs) containing zinc 8-hydroxyquinolinate complexes were prepared by in situ formation route of metal complex in channels of MSNs. The MSNs functionalized with or without mercapto groups had a diameter of 80–170 nm and high surface area (>1010 m 2/g). The 8-hydroxyquinolinate (Hq) was introduced into MSNs containing-zinc ions to form the metalloquinolates by in situ route. The metalloquinolates formed in the channels of MSNs were determined as a single coordination mode (Znq). The novel Znq-MSNs exhibit different optical properties as compared with that obtained by direct chemical adsorption of Znq 2. Especially, the mercapto-modified MSNs exhibited the strong and stable fluorescent emission at about 500 nm in the pH range of 3–10. The obtained fluorescent MSNs were used in the in vitro researches of controlled release for ibuprofen and the imaging for human cervical cancer cells (HeLa).
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