Abstract
BackgroundArtificial lesions produced by different protocols might directly influence the response to different remineralising treatments. This study compared the response of different artificial caries-like enamel lesions to home-care and professional fluoride based-remineralising treatments in situ.MethodsThe tested demineralising protocols were methylcellulose- MC gel, polyacrylic acid - PA gel, tetraethyl methylene diphosphanate - TEMDP solution, and acetate- Buffer solution. The lesions were remineralised using an in situ model, following a crossover and double blind design. Twelve subjects wore intra-oral appliances during 3 phases (3 d each): control (C) (saliva); home-care F− treatment (FD) (1,100 ppm F− dentifrice, 2x1 min/day); and professional (FVD) (22,600 ppm F− varnish) plus FD. The de-remineralisation was measured by transverse microradiography-TMR and hardness (surface hardness/cross-sectional hardness, SH/CSH, respectively).ResultsFor SH, lesions produced by PA gel were the only one showing significant differences among the remineralising treatments (C x FD x FVD); while the TEMDP lesion were not responsive to any fluoride treatment (for both SH/CSH). For TMR, there were no differences among the remineralising treatments, regardless of the type of lesion. Generally, the most responsive lesions to fluoride were the less demineralised lesions (considering hardness: PA gel and Buffer).ConclusionsThe type of lesion has influence on the surface remineralisation degree induced by home-care and professional fluoride treatments using this in situ model.
Highlights
Artificial lesions produced by different protocols might directly influence the response to different remineralising treatments
Hardness data The degree of surface demineralisation (%surface hardness change (SHC)) was higher for tetraethyl methylene diphosphanate (TEMDP) compared to the other protocols, which did not differ from each other except between MC gel and Buffer
When the remineralising treatments were compared, %surface hardness recovery (SHR) significantly increased after both fluoride treatments compared to the control for all type of lesions, except TEMDP
Summary
Artificial lesions produced by different protocols might directly influence the response to different remineralising treatments. The artificial lesions produced by different laboratory protocols significantly differ in respect to mineral distribution and depth [2,3,4,5,6]. Those differences should be considered in the study design, as they might. Four protocols to produce artificial caries-like enamel lesions (methylcellulose- MC gel; polyacrylic acid - PA gel; tetraethyl methylene diphosphanate TEMDP solution and acetate - Buffer solution) were compared, from which TEMDP induced the highest subsurface mineral loss and depth [4]. Some works have investigated the response of different lesions to remineralising agents such as fluoride, they have tested one or two types of artificial caries-like lesions, varying the time of demineralisation
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