Abstract
In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.
Highlights
Over the past few decades, nanofibers have shown immense potential in a broad range of applications such as energy storage [1,2,3], environmental remediation [4], agriculture [5], and filtration [6]
cellulose acetate nanofibers (CANFs) to address the shortcomings associated with poor drug release behavior that is observed with conventional methods for nanofiber-based drug delivery applications such as large-burst drug release, uncontrolled duration of drug release, and incomplete drug release [46,49]
We investigated the effects of poly-AAm hydrogel coating on the drug release profile of cellulose nanofibers (CANFs) loaded with the non-steroidal anti-inflammatory drug (NSAID), ibuprofen
Summary
Over the past few decades, nanofibers have shown immense potential in a broad range of applications such as energy storage [1,2,3], environmental remediation [4], agriculture [5], and filtration [6]. Electrospun nanofibers have been explored in biomedical science for applications encompassing drug delivery systems, diagnostic imaging, theranostics, and tissue engineering [34] They are well suited for these applications because they are readily engineered for specific applications by controlling their structures and properties such as porosity, diameter, stacking, alignment, patterning, surface functional groups, biodegradability, and mechanical properties. One major concern confronting drug delivery systems prepared by electrospinning techniques is the potential for fast dissociation of the drug from the surface layer of the nanofibers, a phenomenon known as burst release [46] To overcome this challenge, drugs can be coated with monodispersed core/shell particles with the outer layer of polymer. The resulting data suggest a promising performance of the material for potential applications in wound dressing
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