Abstract
In situ gel with ion activated system which occurs as triggered by a change in the ionic strength. Osmotic gradient is a factor that determines the rate of gelation on the surface of the gel. Polymers play an important role in drug delivery from their dosage forms. Polymeric in gelling systems provides longer drug release compared to conventional delivery systems. The use of biodegradable and biocompatible polymers for in situ gel formulation makes the drug delivery system acceptable and controlled. Thus the continuous and prolonged release of the drug, biocompatibility characteristics makes the dose gel form in situ reliable. Polymers that are used in ion activated in situ gelation can be various, such as gelrite gellan gum, alginates, deacetylated gellan gum, anionic polymers (carbopol), cationic polymer (chitosan), non-ionic polymers (HPMC, Methylcellulose), thiolated polymer (thiomers), carbomer (polymer used in ophthalmic), polycarbophil (polymer used in ophthalmic). This review is written based on the data or information obtained by using several search engines and several scientific journals, using the keywords in situ gel with polymers, ion activated the system, and limited search years in 2010 and above.
Highlights
The goal of pharmacotherapeutics is to treat a disease in a consistent and predictable fashion
The drops provide therapeutically effective concentrations that have been the preferred route of administration for bacterial conjunctivitis and keratitis because the drops wash away bacteria and bacterial antigens; adverse systemic effects of the drugs are decreased or eliminated [1]
Polymeric in gelling systems provides longer drug release compared to conventional delivery systems
Summary
The goal of pharmacotherapeutics is to treat a disease in a consistent and predictable fashion. In situ gelling systems developing are to prolong the precorneal residence time of a drug, enhance ocular bioavailability, and improve patient compliance. Balasubramaniam and Pandit prepared and evaluated ion-activated in situ gelling systems for sustained ophthalmic delivery of ciprofloxacin hydrochloride (CPH).
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