In Situ Neutral System Synthesis, Spectroscopic, and Biological Interpretations of Magnesium(II), Calcium(II), Chromium(III), Zinc(II), Copper(II) and Selenium(IV) Sitagliptin Complexes.

Samy M El-Megharbel,Reham Z Hamza,Fawziah A Al-Salmi,Moamen S Refat

doi:10.3390/ijerph18158030

Abstract

Magnesium(II), calcium(II), chromium(III), zinc(II), copper(II), and selenium(IV) sitagliptin (STG) complexes—with the general formulas [Mg(STG)2(Cl)2]·6H2O, [Ca(STG)2(Cl)2], [Cr(STG)2(Cl)2]Cl.6H2O, [Zn(STG)2(Cl)2], [Cu(STG)2(Cl)2]·2H2O, and [Se(STG)2(Cl)2]Cl2, respectively—were designed and synthesized by the chemical reactions between metal(II, III, and IV) chloride salts with an STG ligand in situ methanol solvent in a 1:2 stoichiometric ratio (metal:ligand). Tentative structures of the complexes were proposed based on elemental analysis, molar conductance, magnetic moments, thermogravimetric analysis, and spectral (infrared, electronic, and 1H NMR) data. The particle size and morphological investigation were checked on the bases of scanning electron microscopy, transmission electron microscopy, and X-ray powder diffraction analyses. All the Mg2+, Ca2+, Cr3+, Zn2+, Cu2+, and Se4+ complexes were found to be six-coordinated, wherein the STG ligands act as bidentate chelating agents. This study demonstrates that pancreatic tissues are affected by the induction of experimental diabetes mellitus and clarifies the potential of the synthesized STG complexes, which was found to more significantly improve insulin secretion and the pancreatic and glycometabolic complications of diabetic rats than STG alone.

Highlights

Metal ions play important roles in our life processes
Electrolytic measurements of the trivalent chromium and Se(IV) complexes revealed that their 1:1 electrolytic nature, which suggests that one or two Cl- anions exist outside the coordination sphere [25]
The dissolution of these two synthesized STG complexes gave a white precipitate when mixed with an AgNO3 reagent, which confirmed the existence of a Cl- ion in the outer coordination sphere

Summary

Introduction

Metal ions play important roles in our life processes. It is well known that that both cellular and semi-cellular functions involve metals. The vital role of inorganic salts in living systems can be revealed by studying biological and biochemical systems. The chemistry of inorganic compounds is not the “dead chemistry” that lot of people may imagine [1,2,3]. Metal ions are as important components of life as organic compounds. In cells, Mg+2 and Ca+2 ions play regulatory important roles. Metallothionine proteins are rich in mineral ions. The formation of protein complexes involves the transportation of Fe and other metals by blood plasma [1]. The focus in this article is on of metal molecule interactions, as well as the chemistry and structure of metal complexes [1,2,3,4,5,6,7,8,9,10]

Results

Discussion

Conclusion