Abstract
Such hydrogels are of par-ticular interest because drugs, proteins and cells can beincorporated easily into polymer solutions prior to adminis-tration and the polymer solution can be injected into thebody without invasive surgical procedures. This method hasbeen developed using thermosensitive polymers or byemploying particular chemical or photochemical reactions.Amphiphilic block or graft copolymer solutions that trans-form from a sol state (flow) to a gel state (non-flow) uponchanges in pH and temperature can be injected subcutane-ously into the target site. In particular, thermo-reversiblehydrogels from amphiphilic block copolymer consisting ofhydrophilic poly(ethylene glycol) (PEG) and hydrophobicaliphatic polyester, such as poly(lactic acid-
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