In-Situ Gel-New Formulation Trend

Abstract

This review on in situ gel was written to fill in any gaps in the current body of knowledge, with a special emphasis on in-situ gelling systems that prolong the residence time of drugs at their targets. Drugs with very short half-lives and high solubility are especially interested in in-situ gels. The use of in-situ gelling systems as drug delivery systems for both local and systemic effects has recently been developed. The advantages of in-situ polymeric delivery systems, such as ease of administration, decreased frequency of administration, enhanced patient compliance, and comfort, have drawn the most attention in current in-situ gelling system development. The studies that evaluated the use and performance of these systems are summarized in this review. This review paper is prepared to highlight formulation considerations employed during the development of an in-vivo drug delivery system, pertinent biodegradable polymers for the sol-gel transition, characterization, assessment criteria, and commercial formulations of the in-vivo polymeric system.