Abstract
AbstractChemically crosslinked hydrogels are prepared at remarkably low macromonomer concentrations from 8‐arm poly(ethylene glycol)‐poly(L‐lactide) star block copolymers bearing acrylate end groups (PEG‐(PLLAn)8‐AC, n = 4 or 12) and multifunctional PEG thiols (PEG‐(SH)n, n = 2, 4, or 8) through a Michael‐type addition reaction. Hydrogels are obtained within 1 min after mixing PEG‐(PLLA4)8 ‐AC and PEG‐(SH)8 in phosphate buffered saline, quickly reaching a high storage modulus of 17 kPa. Lysozyme and albumin are released for 4 weeks from PEG‐(PLLA12)8‐AC/PEG‐(SH)8 hydrogels. Lysozyme release from PEG‐(PLLA12)8‐AC/PEG‐(SH)2 and PEG‐(PLLA12)8‐AC/PEG‐(SH)4 hydrogels is significantly faster with complete release in 3 and 12 d, respectively, as a result of a combination of degradation and diffusion.
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