Abstract
The rapid dissolution rate of many water-soluble, immediate release solid dosage forms requires a dissolution analyzer that is fast,sensitive,customizable for frequent measurements,and able to generate data of high precision and quality.These requirements fit perfectly with today’s in situ fiber optic technology.The Rainbow Dynamic Dissolution Monitor was used in this study to demonstrate and evaluate the dissolution behavior of 500 mg Vitamin B12 (cyanocobalamin) tablets in degassed water, simulated gastric fluid (SGF),and phosphate buffer at stirring speeds as high as 100 rpm. Upon dissolution,Vitamin B12 tablets produce rather turbid suspensions that may be expected to cause problems for in situ measurements. However, the effect of light scattering by suspensions is largely eliminated when the second derivative of the absorbance signal is used in quantitation. Excellent data correlation was observed between the different media and the standard when using this method. Figure 1: Structure of cyanocobalamin (Vitamin B12) dx.doi.org/10.14227/DT100403P20
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