In situ degradation of antibiotic residues in medical intravenous infusion bottles using high energy electron beam irradiation

Min Wang,Tao Pang,Dongqing Cai,Xin Zhang,Lele Zhang,Zhengyan Wu,Guilong Zhang

doi:10.1038/srep39928

Abstract

This study reported an immediate approach for the degradation of three antibiotic (amoxicillin, ofloxacin, and cefradine) residues in medical intravenous infusion bottles (MIIBs) using high energy electron beam (HEEB) irradiation. The effects of irradiation doses, initial concentrations, initial pH, and scavengers of active radicals on the degradation of three antibiotic residues (ARs) were investigated, and the results displayed that 97.02%, 97.61% and 96.87% of amoxicillin, ofloxacin, and cefradine residues could be degraded in situ through HEEB irradiation respectively. Fourier transform infrared spectroscopy (FTIR) and high performance liquid chromatography-mass spectrometry (HPLC-MS) analysis demonstrated that ARs were mainly decomposed into inorganic ions and alkanes. Typically, the detailed degradation mechanism of ARs was also investigated, and the dominant active particle inducing the degradation of antibiotics during the HEEB irradiation process was demonstrated to be hydroxyl radical.

Highlights

Veterinary medicines for their effective broad spectrum against a wide variety of microorganisms[1,3,6,18]
When the initial concentration of antibiotic residues (ARs) was below 50 mg L−1, the degradation efficiency (DE) of each AR almost decreased with the increasing initial AR concentration when the irradiation dose was lower than 20 kGy, and reached nearly same value when the dose was higher than 30 kGy
This was because the ratio decreased with the increasing initial AR concentrations when the dose was lower than 20 kGy, while the active particles were sufficient for the degradation of almost all the AR molecules with dose higher than 30 kGy

Summary

Introduction

Veterinary medicines for their effective broad spectrum against a wide variety of microorganisms[1,3,6,18]. The effects of initial concentrations of antibiotics, HEEB irradiation doses, pH of initial solutions, and common coexistent substances on AR degradation behavior were studied in detail to obtain the optimal degradation condition, and the reaction mechanism was investigated

Methods

Results

Conclusion