Abstract
In situ forming hydrogels are a class of biomaterials that can fulfil a variety of important biomedically relevant functions and hold promise for the emerging field of patient-specific treatments (e.g., cell therapy, drug delivery). Here we report the results of our investigations on the generation of in situ forming hydrogels with potential for wound healing applications (e.g., complex blast injuries). The combination of polysaccharides that were oxidized to display aldehydes, amine displaying chitosan and nanostructured ZnO yields in situ forming bionanocomposite hydrogels. The physicochemical properties of the components, their cytotoxicity towards HaCat cells and the in vitro release of zinc ions on synthetic skin were studied. The in situ gel formation process was complete within minutes, the components were non-toxic towards HaCat cells at functional levels, Zn2+ was released from the gels, and such materials may facilitate wound healing.
Highlights
Biomaterials to facilitate wound healing are designed to cover wounds, prevent infection and help injured tissues to repair and regenerate with an improved rate of healing [1]
We report the generation of in situ forming hydrogels formed by imine formation between amines displayed on CS and aldehydes displayed on oxidized derivatives of HA or pectin (Figure 1)
The release profiles of Zn2+ from the bionanocomposite hydrogels was studied over the period of 8 h (Figure 4), with release of Zn2+ at a rate of ~100 μg per hour for both formulations, which is potentially useful for wound
Summary
Biomaterials to facilitate wound healing are designed to cover wounds, prevent infection and help injured tissues to repair and regenerate with an improved rate of healing [1]. Scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDS) confirmed the homogeneous dispersion of the NsZnO particles inside the polymeric matrix (Figure A2). The release profiles of Zn2+ from the bionanocomposite hydrogels was studied over the period of 8 h (Figure 4), with release of Zn2+ at a rate of ~100 μg per hour for both formulations (there was no statistically significant difference between the formulations), which is potentially useful for wound. The release profiles of Zn2+ from the bionanocomposite hydrogels was studied over the period of 8 h (Figure 4), with release of Zn2+ at a rate of ~100 μg per hour for both formulations (there was no statistically significant difference between the formulations), which is potentially useful for wound hJ.eFaulninctg.
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