Abstract

Functionalized furanose-fused piperidines 4- 6 and oxazepines 15- 17 , useful precursors for structurally unique bioactive nucleosides as well as for potential glycosidase inhibitors, have been synthesized by the application of 1,3-dipolar azide cycloaddition (DAC) reaction on d-glucose based substrates. The strategy works well even with the nucleoside analogue 8 , affording the bicyclic nucleoside analogues 11 and 12 .

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