In silico study of the ageing effect upon aortic valves

Abstract

A fluid–structure interaction (FSI) numerical model of the aortic valve was used to simulate and compare young and physiological aged operating conditions. The effect of normal ageing was considered by introducing alterations typically associated with senility: namely mild stiffening of the tissues and progressive dilation of the aortic chamber. The aim of this study is to provide a haemodynamic baseline which allows to assess the typical physiological variations associated with advancing age. Results were analysed in terms of leaflets kinematics, flow dynamics, pressure and valve performance parameters. The study indicates that the normal changes occurring with ageing, such as stiffening and progressive aortic root dilation, can result in substantial alterations in the haemodynamics and mechanical efficiency of the aortic valve. In particular, mild tissue stiffening and aortic root dilation reduce the valve efficiency over the cardiac cycle. The concomitant presence of both phenomena can lead to some mitigation of the impairment. The observed changes, which can be associated with normal and healthy ageing, need to be taken into consideration when evaluating the real pathological contribution of aortic valve diseases occurring in aged patients.