In-Silico Study of Chicoric acid as an Adjunct Therapy Targeting Caspase-3 for Effective Management of Heart Failure

Abstract

Heart failure is a significant public health problem and it is one of the most prevalent reasons for being admitted to the hospital. It mostly affects the elderly, and with rising life expectancy and better management of chronic medical diseases, the patient population with heart failure is predicted to rise. As there are many side effects of existing drug interventions that are being used to manage the heart failure issue, the surge to explore alternative traditional medicine has regained all interest. Therefore, this study aims to identify a potential inhibitor of a novel target for heart failure “caspase-3” which plays an important role in the failing of the heart using a computational approach of molecular docking. The study explores the targeting ability of chicoric acid which is one of the phytocompound presented in various botanical sources having cardioprotective nature. The results of the study revealed a negative binding affinity of -15.46Kcal/mol which is promising for the development of alternative treatment or an adjunct for effective heart failure management.