In-silico Study of an Ethnobotanical Plant; Urtica dioica for Assessing Anti-diabetic Potential

Abstract

Urtica dioica L (Bicchu buti) is anethnobotanical plant.It is a wild herbaceous perennial plant found in the Himalayan region of India and commonly known as stinging nettle. It has ethnobotanical importance, and is used to treat various disorders since ancient times.The aim of this paper is in-silico study of the U. dioica’s phytochemicals on the glucose metabolism related to alpha-amylase. Therefore, in this research, we have assessed the anti-diabetic potential of U. dioica found in Ranikhet tehsil, by in-silico method. Hence, weconducted molecular docking of phytochemicals with a molecular anti-diabetic target i.e., alpha-amylase. From our study, we found4 potential phytochemicals namely; Ursolic acid, Pinoresinol , Beta-Sitosterol, and (-)-Pinoresinol which could be useful in effective drugdevelopment and helpful in the treatment of diabetes problems