Abstract
Research have been conducted screening in silico chemical com pound inhibitor α - glucosidase from plants dringo ( Acorus calamus L ) based on the binding site (binding site) are owned by some of the compounds obtained respectively from the inhibition of enzyme / receptor (docking) us ing the program Argus Lab. Model of t he enzyme α - glucosidase was obtained through the protein data bank with the code 1lwj in the donwload NCBI website. Models of chemical compounds contained in dringo ( A. Calamus L) obtained through the site Take out jamu Knapsack and made in the formul a structures of 2D and 3D using the program ACD / Chemsketch. Docking results showed activity in the compound 1 - ethenyl - 1 - methyl - 2,4 - at (prop - 1 - en - 2 - yl) Cyclohexane with free energy - 8.04385 kcal / mol, and the compound Isocaespitol with a free energy - 8.28388 kcal / mol.
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