In-Silico QSAR Studies of Some Pyrazolone Compounds

Abstract

In-silico studies are fascinating the workers/scientists working in the field of drugs designing. The present paper includes QSAR studies related to some novel substituted pyrazolone derivatives. A series of seven pyrazolone compounds is taken for these studies. All the compounds were evaluated for antimicrobial activity against six different microbes viz. bacterial and fungal microbes. Their reported antimicrobial activities were used for Quantitative Structure Activity Relationship (QSAR) studies. The correlation between different computed molecular descriptor of the compounds with their reported biological activities has also been studied and reported in the paper.