Abstract
Background B cell epitopes corresponding to interaction zones between proteins and immune system are a mean to explore intrinsic features of proteins linked to allergenicity. The project PREDEXPITOPE was funded by the French National Research Agency to develop a bioinformatics strategy for prediction of B cell epitopes of allergens. The objective was to distinguish epitopic from non epitopic areas on the basis of frequently used criteria of surface exposition. In silico prediction was confronted with experimental results on wheat allergens.
Highlights
B cell epitopes corresponding to interaction zones between proteins and immune system are a mean to explore intrinsic features of proteins linked to allergenicity
In silico prediction was confronted with experimental results on wheat allergens
The amino acids within epitopes are not distributed above any threshold for both relative surface accessibility and protrusion index
Summary
In silico prediction of B cell epitopes and experimental validation on wheat allergens Sandra Denery-Papini1*, Virginie Lollier[1], Hamza Mameri[1], Manon Pietri[1], Colette Larre[1], Jean-Charles Gaudin[1], Olivier Tranquet[1], Martine Drouet[2], Evelyne Paty[3], Anne-Marie Jonathan[4], Etienne Beaudouin[5], Anne Denise Moneret-Vautrin[5], Dominique Tessier[1]. From 5th International Symposium on Molecular Allergology (ISMA 2013) Vienna, Austria. From 5th International Symposium on Molecular Allergology (ISMA 2013) Vienna, Austria. 6-7 December 2013
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