Abstract
Organogenesis is a dynamical multi‐scale process in which large‐scale features (such as the geometric conformation of the tissue) directly feeds back onto the regulation of molecular‐scale events such as gene regulation. Our attempts to capture this process must therefore focus as much on morphometry as molecular biology. Here I will describe our work to transform a classical model of developmental biology – the developing vertebrate limb bud – into a quantitative model system for systems biology and multiscale modeling. In particular, we have developed: (a) 3D and 4D quantitative data‐capture tools[1], and (b) new multiscale simulation software. This integrated approach is allowing us to combine two of the primary questions of organogenesis: mechanical morphogenesis (the active cellular movements which lead to shaping of the tissue [2,3]), and molecular patterning (the spatial regulatory networks which control gene expression ‐ [3] and unpublished work).
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
