In-silico Molecular Interaction Studies of Biologically Active Secondary Metabolites of Cissus quadrangularis L. as a Potential Anti-cancer Drug

Abstract

Cissus quadrangularis Linn. is a succulent perennial plant of family Vitaceae also called as Asthisandhaanak or Hadjor in Hindi, has been traditionally described in Ayurveda and Siddha literature as general tonic and as a powerful analgesic, used as an anti-cancer, antidiabetic, antibacterial, hepatoprotective and neuroprotective etc. It is a good source of biologically active secondary metabolites withvarious pharmacological activities implicated in a wide range of human diseases. Cancer is a major issue or concern in public health systems, especially in developing countries like India. Matrix metalloproteinases (MMP), Tyrosine kinase (TK) and Vascular endothelial growth factor (VEGF) are emerging as an important cancer target therapeutic proteins. Molecular docking studies provide a better insight into the biological activity of secondary metabolites like Resveratrol (3,4′,5-trans-trihydroxystilbene) and Piceatannol (3,3′,4,5′-transtrihydroxystilbene) from C. quadrangularis L., its possible mechanisms of action, binding modes and predicting it as a possible anti-cancer drug with and lesser or no side effects